Sovaldi (sofosbuvir) is an antiviral medication that prevents hepatitis C virus (HCV) cells from multiplying in your body.
Sovaldi is used in combination with other medications to treat hepatitis C in adults. Sofosbuvir is sometimes used in people who also have HIV, or people who have liver cancer and are going to have a liver transplant. This medicine is not a treatment for HIV or AIDS.
Sovaldi must be given in combination with other antiviral medications and should not be used alone. Sovaldi is usually given with ribavirin (Copegus, Rebetol, Ribasphere, RibaTab) with or without peginterferon alfa (Pegasys, PegIntron).
Sovaldi is also used together with Daklinza (daclatasvir) to treat hepatitis C genotype 3 infection in adults.
Administer SOVALDI in combination with ribavirin or in combination with pegylated interferon and ribavirin for the treatment of HCV. The recommended treatment regimen and duration for SOVALDI combination therapy is provided in Table 1.
SOVALDI in combination with ribavirin for 24 weeks can be considered as a therapeutic option for patients with genotype 1 infection who are ineligible to receive an interferon-based regimen [see Clinical Studies (14.4)]. Treatment decision should be guided by an assessment of the potential benefits and risks for the individual patient.
Do not use with severely impaired renal function.
Note that the application of acyclovir may develop acute renal failure due to precipitate formation of crystals of acyclovir, which is especially likely during rapid IV introduction, the simultaneous use of nephrotoxic drugs in patients with impaired renal function and lack of water stress.
When applying aciclovir should monitor renal function (determination of the level in the blood urea nitrogen and creatinine in blood plasma).
Treatment of elderly patients should be conducted with a sufficient increase in water load and under the supervision of a physician, because among these patients increased half-life of acyclovir.
In the treatment of genital herpes should avoid sex or use condoms, because use of acyclovir does not prevent transmission to partners.
This medication acyclovir in the form of dosage forms for topical use should not be applied to mucous membranes of the mouth, eyes, vagina.
It is possible that some side effects of Sovaldi may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
As well as its needed effects, sofosbuvir (the active ingredient contained in Sovaldi) may cause unwanted side effects that require medical attention.